Thank you.
So the alignment with the valve stem is just coincidental. There is a red mark on the tire (which apparently I have not noticed...).
Correction. I just found this in Ewing's Concise Guide to the DA62:
**
Red dot on tire sidewall indicates tire’s point of lowest mass
During installation, red dot is aligned with the valve stem which is the heaviest mass on the inner tube
Main wheel covers hide the valve stem, so alignment arrow on cover indicates valve stem position
CAUTION: If red slip mark on the wheel cover is not aligned with red dot on tire, the wheel should be inspected by an authorized mechanic
**
I don't have wheel covers (possibly a change when they went to Beringer wheels/brakes) but I do believe there is a red mark on the rim.